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94 and 211.113(b)).  This can be to protect the Conditioning for use of your remaining containers or closures along with to be certain sample integrity, if they are for being examined for microbial contamination.  In a minimal, any sampling should be done in a fashion to limit publicity to your setting all through and following the time samples a

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Essential weighing, measuring, or subdividing operations must be witnessed or subjected to an equivalent Manage. Just before use, production staff really should verify that the supplies are All those laid out in the batch record with the intended intermediate or API.Inside a bank, for instance, so-named stop-of-working day (EOD) Work opportunities

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